WebBackground/aims: Increased production of multiple pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, plays an essential pathogenic … WebJun 2, 2024 · Metrics. Itaconate is an immunomodulatory Krebs cycle-derived metabolite. Description of two isomers of itaconate, mesaconate and citraconate, which have …

Itaconate is an anti-inflammatory metabolite that activates ... - Nature

WebJan 6, 2024 · Bambouskova et al. demonstrated that due to their electrophilic properties, itaconate and its derivatives react with glutathione and induce both Nrf2-dependent and Nrf2-independent responses; moreover, they showed that the electrophilic stress caused by itaconate can regulate the IL-6 response, which is a regulatory secondary transcriptional … WebZhang et al. report that the metabolite itaconate alkylates transcription factor TFEB, a master regulator of lysosomal biogenesis, at Cys212 to reduce its cytosolic retention … peliculas wes anderson

The STING1-MYD88 complex drives ACOD1/IRG1 expression and …

WebItaconate is one of the best examples of the consequences of metabolic reprogramming during immunity. It is made by diverting aconitate away from the tricarboxylic acid cycle during inflammatory macrophage activation. The main reason macrophages exhibit this response currently appears to be for an anti-inflammatory effect, with itaconate ... WebAbstract. Itaconate is an immunoregulatory and anti-bacterial metabolite, and plays important roles in host–pathogen interactions. Chemoproteomic strategies have been used to explore the anti-inflammatory effects of itaconate on activated macrophages and it has been found that many key proteins in immune pathways were modified; however, how … WebMay 12, 2024 · The Biosynthesis and Metabolism of Itaconate. TCA cycle is a complex biological process involving a series of enzyme-catalyzed reactions for Adenosine triphosphate (ATP) production in the mitochondrial matrix (Martínez-Reyes and Chandel, 2024).The unique and crucial step in the biosynthesis pathway of itaconate is the … peliculas sword art online