WebSialic acids are critical components of many glycoconjugates involved in biologically important ligand-receptor interactions. Quantitative and structural variations of sialic acid residues can profoundly affect specific cell-cell, pathogen-cell, or drug-cell interactions, but manipulation of sialic acids in mammalian cells has been technically limited. We describe … WebOct 1, 2010 · Neutralization of carboxylic acid is an important means to avoid sialic acid dissociation when sialylated glycans are analyzed by matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS). In this paper, we describe a simple and rapid method to modify the sialic acids of sialylated gl …
Unravelling the specificity and mechanism of sialic acid ... - Nature
WebMar 17, 2024 · This chemistry has addressed the limitations of MS analysis for sialylated ... and erythropoietin have recently been characterized by means of linkage-specific sialic … WebDec 18, 2009 · Sialic acids are a subset of nonulosonic acids, which are nine-carbon α-keto aldonic acids. Natural existing sialic acid-containing structures are presented in different sialic acid forms, various sialyl linkages, and on diverse underlying glycans. They play important roles in biological, pathological, and immunological processes. ip university llb admission
Sialic acids in fungi SpringerLink
WebDefective lysosomal egress of free sialic acid (N-acetylneuraminic acid) in fibroblasts of patients with infantile free sialic acid storage disease. J Biol Chem 1989;264:15316–22. 5. Sewell AC. Urinary screening for disorders of complex heteroglycan metab-olism: results of 10 years experience with a comprehensive system. Klin Wochenschr 1988 ... Sialic acids are a class of alpha-keto acid sugars with a nine-carbon backbone. The term "sialic acid" (from the Greek for saliva, σίαλον - síalon) was first introduced by Swedish biochemist Gunnar Blix in 1952. The most common member of this group is N-acetylneuraminic acid (Neu5Ac or NANA) found in animals and … See more The sialic acid family includes many derivatives of the nine-carbon sugar neuraminic acid, but these acids rarely appear free in nature. Normally they can be found as components of oligosaccharide … See more Sialic acid containing glycoproteins (sialoglycoproteins) bind selectin in humans and other organisms. Metastatic cancer cells often express a high density of sialic acid-rich … See more Sialic acids are found at all cell surfaces of vertebrates and some invertebrates, and also at certain bacteria that interact with vertebrates. See more Rat pups supplemented with sialic acid showed improved learning and memory as adults. A relationship between dietary sialic acid supplementation and cognitive function was seen in piglets that had been fed high doses of sialic acid. See more Sialic acid is synthesized by glucosamine 6 phosphate and acetyl-CoA through a transferase, resulting in N-acetylglucosamine-6-P. This becomes N-acetylmannosamine-6-P through epimerization, which reacts with phosphoenolpyruvate producing … See more The synthesis and degradation of sialic acid are distributed in different compartments of the cell. The synthesis starts in the cytosol, where N-acetylmannosamine 6 … See more Sialic acids are related to several different diseases observed in humans. Sialic acid deficiency with mutations in the NANS gene Biallelic recessive mutations in the sialic acid synthesis gene, N-acetyl-neuraminic acid synthase … See more WebThe Svennerholm resorcinol method for the quantitative determination of the sialic acids was modified by introducing a periodate oxidation step prior to heating with the resorcinol … orange and bergamot perfume