WebMay 2, 2024 · In dose escalation of the ongoing first-in-human study in heavily pretreated patients with advanced refractory solid tumors (NCT03917381), GEN1046 demonstrated pharmacodynamic immune effects in peripheral blood consistent with its mechanism of action, manageable safety, and early clinical activity [disease control rate: 65.6% (40/61)], … WebMethods: This Phase 1a trial uses a modified 3+3 dose-escalation design to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary anti-tumor activity in subjects …
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WebThus, we conducted this phase II study to assess the antitumor activity of adavosertib in patients with CCNE1-amplified, advanced refractory solid tumors.PATIENTS AND METHODSPatients aged ≥ 18 years with measurable disease and refractory solid tumors harboring CCNE1 amplification, an Eastern Cooperative Oncology Group performance … WebJun 20, 2006 · We report results from a Phase I study of weekly doses of intravenous ADH-1 given to patients with N-cad+ solid tumors, to evaluate safety, PK, antitumor activity, and effect of ADH-1 on tumor vasculature assessed by DCE-MRI. Methods: ADH-1 starting dose was 150 mg/m 2 administered weekly for 3 W in 28 D cycles. psmas chiredzi
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WebApr 13, 2024 · Refractory or resistant CMV after organ transplantation is challenging for clinicians and patients. Learn about the changing treatment landscape. ... (CMV) in patients after solid organ transplantation (SOT). A panel of infectious diseases experts review current CMV treatment guidelines, discuss antiviral resistance testing, and provide ... WebApr 15, 2024 · 2.1 Patient Selection. Patients aged ≥ 21 with histologically or cytologically confirmed, advanced, refractory solid tumors unresponsive to standard anti-cancer … WebMar 19, 2024 · The meaning of refractory cancer is cancer that fails to respond to medical treatment. This may present as resistance to treatment from the start, or the acquisition … horses daryl braithwaite tab