WebThe enzyme phosphoglucose isomerase, shown here from PDB entry 1hox , takes glucose-6-phosphate and shuffles a few atoms, forming fructose-6-phosphate, shown here in yellow. The enzyme can do this reaction in either direction. So when glucose-6-phosphate is plentiful in the cell, it converts it to fructose-6-phosphate, and when fructose-6 ... WebJul 28, 2000 · The crystal structure of phosphoglucose isomerase/autocrine motility factor/neuroleukin complexed with its carbohydrate phosphate inhibitors suggests its …
Structural Basis for Phosphomannose Isomerase Activity in ...
WebOct 12, 2004 · Structural Basis for Phosphomannose Isomerase Activity in Phosphoglucose Isomerase from Pyrobaculum aerophilum: A Subtle Difference between Distantly Related Enzymes† Michael K. Swan, Thomas Hansen, Peter Schönheit, and ; Christopher Davies WebGlucose phosphate isomerase (GPI) deficiency is an inherited disorder that affects red blood cells, which carry oxygen to the body's tissues. People with this disorder have a condition known as chronic hemolytic anemia, in which red blood cells are broken down (undergo hemolysis) prematurely, resulting in a shortage of red blood cells ( anemia ). hill refrigeration cases
PDB-101: Molecule of the Month: Glycolytic Enzymes
WebTriose phosphate isomerase isomerization reaction concerted general acid-base catalysis involving low-barrier H-bonds ... pK = 6.5 (Glu, His) and pK = 9.5 (Lys) loop structure gives stereoelectronic control diffusion-controlled reaction (catalytic perfection) Reactions of Glycolysis Glyceraldehyde-3-phosphate dehydrogenase ... phosphoglucose ... WebThe GPI gene provides instructions for making an enzyme called glucose phosphate isomerase (GPI). This enzyme has two distinct functions based on its structure. When two GPI molecules form a complex (a homodimer), the enzyme plays a role in a critical energy-producing process known as glycolysis, also called the glycolytic pathway. WebSep 17, 2004 · Phosphoglucose isomerase (PGI) is an enzyme of glycolysis that interconverts glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P) but, outside the cell, is a multifunctional cytokine. High-resolution crystal structures of the enzyme from mouse have been determined in native form and in complex with the inhibitor erythrose 4 … hill realty somerset