Webtriggered by hypoxia is early growth response protein 1 (EGR1). EGR1 is part of a family of immediate early genes that can be stimulated by a wide range of physiological stimuli, one of which is hypoxia. EGR1 regulates many genes in response to extracellular stimuli and plays a critical role in cellular growth, development and differentiation (1). WebAug 1, 2024 · Using low-stringency hybridization with an EGR1 ( 128990) cDNA probe, Joseph et al. (1988) identified a distinct human cDNA, designated EGR2 (early growth response gene-2). The cDNA sequence predicts a protein of 406 amino acids, including 3 tandem zinc fingers of the cys (2)-his (2) class. The deduced amino acid sequences of …
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WebF The Egr1-Deficient Model. Early growth response protein 1 (Egr1) is a transcription factor that is rapidly induced by growth factors, cytokines, and stress signals such as radiation, injury, or mechanical stress to transduce signals to the downstream cascades, which is involved in cell proliferation and apoptosis regulation. WebMay 1, 2011 · The early growth response (Egr) transcription factors belong to a family comprising Egr-1 (alias Krox-20), Egr-2 (alias Krox-24), Egr-3, and Egr-4, along with their endogenous inhibitors, NGFI-A binding protein (NAB1 and NAB2). 6, 7 These pleiotropic early-immediate gene products are induced in response to multiple extracellular signals, … dibels progress monitoring grade 2
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WebJul 7, 2024 · We analyzed whole transcriptome expression to elucidate the potential role and underlying mechanism of action of lipocalin-2 (LCN2) in OPC differentiation and WMI and identified the receptor SCL22A17 and downstream transcription factor early growth response protein 1 (EGR1) as the key signals contributing to LCN2-mediated … WebPreviously, we demonstrated that CO inhibits lipopolysaccharide (LPS)-induced expression of the proinflammatory early growth response-1 (Egr-1) transcription factor in macrophages via activation of PPARγ. Here, we further characterize the molecular mechanisms by which CO modulates the activity of PPARγ and Egr-1 repression. WebMay 2, 2024 · Figure 4 Renal early growth response factor-2 (EGR2) expression in wild-type and transforming growth factor-beta1 (TGF-β 1) transgenic mouse strains. At 14 days of age, EGR2 increased markedly in only CBAxB6-TGFβ kidneys, at both the ( a ) mRNA and ( b ) protein levels. citipost owl gmbh \\u0026 co. kg