Web•DILAUDID-HP INJECTION is for opioid-tolerant patients only and should be used only if the amount of hydromorphone required can be delivered accurately with this formulation. (2.2) •Hepatic Impairment: Initiate treatment with one-fourth to one-half the usual starting dose, depending on degree of hepatic impairment. (2.3) WebJan 6, 2012 · In patients with moderate hepatic impairment, C max and AUC were increased 4-fold after single-dose administration of oral immediate-release …

Analgesic use in adults with liver disease - UpToDate

WebFor hydromorphone hydrochloride. For immediate-release capsules, manufacturer advises swallow whole capsule or sprinkle contents on soft food. For modified-release capsules, manufacturer advises swallow whole or open capsule and sprinkle contents on soft cold food (swallow the pellets within the capsule whole; do not crush or chew). WebAug 11, 2024 · Hepatic Impairment. The pharmacokinetics of hydromorphone is affected by hepatic impairment. Due to increased exposure of hydromorphone, patients with hepatic impairment should be started at one-fourth to one-half the recommended starting dose depending on the degree of hepatic dysfunction and closely monitored during dose … djevrek

Opioid Dosing in Renal and Hepatic Impairment - Medscape

WebImmediate release hydromorphone. ... Patients with moderate hepatic impairment should be started at a lower dose and closely monitored during dose titration. Renal impairment: Reduced excretion (may need reduced dosing frequency). Titrate slowly and monitor carefully in mild to moderate renal impairment. Avoid in chronic kidney disease stages 4 ... WebNov 24, 2024 · Hydromorphone and oxymorphone are semisynthetic derivatives of morphine and potent opiate agonists which are used predominantly to treat moderate-to … http://patientsafety.pa.gov/pst/Documents/HYDROmorphone/insert.pdf djevt