Cullin 3 antibody
WebThe CUL3 gene provides instructions for making a protein called cullin-3. This protein plays a role in the cell machinery that breaks down (degrades) unwanted proteins, called the ubiquitin-proteasome system. Cullin-3 is a core piece of a complex known as an E3 ubiquitin ligase. E3 ubiquitin ligases function as part of the ubiquitin-proteasome ... WebCullin 3 antibody LS-C313077 is an unconjugated rabbit polyclonal antibody to Cullin 3 (CUL3) (aa426-444) from human. It is reactive with human, mouse, rat and other …
Cullin 3 antibody
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WebMay 12, 2024 · MLN4924, a neddylation inhibitor of Cullin-Ring E3 ligases, dramatically reduced the proliferation of tumor cells, especially CUL3-overexpressing cells, which showed that BECN1 degradation mediated by CUL3 could be an effective therapeutic target for breast cancer. Results BECN1 protein level is regulated through the ubiquitin … WebAnti-Cullin 3 antibody produced in rabbit (Anti-CUL3); ~ 1.0mg/mL, affinity isolated antibody, buffered aqueous solution; Suitable for indirect immunofluorescence; Cullin 3 …
WebOct 5, 2016 · Multiple Cullin-RING ubiquitin ligase (CRL) complexes were identified. Importantly, inhibition of cullin-3 (Cul3) or RING-box protein 1 (Rbx1), by siRNA silencing or chemical perturbation, significantly impairs strain-specific NSP1-mediated β-TrCP degradation. ... Fluorescent Antibody Technique HEK293 Cells Host-Parasite …
WebThe cullin family proteins are scaffold proteins for the Ring finger type E3 ligases, participating in the proteolysis through the ubiquitin-proteasome pathway. Humans express seven cullin proeins: CUL1-3, CUL4A, CUL4B, CUL5, and CUL7. Each cullin protein can form an E3 ligase similar to the prototype Ring-type E3 ligase Skp1-CUL1-F-box complex. WebMar 29, 2024 · Cullin3 (CUL3) suppresses proliferation, migration and phenotypic transformation of PDGF-BB-stimulated vascular smooth muscle cells and mitigates inflammatory response by repressing Hedgehog signaling pathway. Xiang Y, et al. Bioengineered, 2024 Dec. PMID 34699319, Free PMC Article
WebAnti-Cullin 3/CUL-3 antibody See all Cullin 3/CUL-3 primary antibodies Description Rabbit polyclonal to Cullin 3/CUL-3 Host species Rabbit Tested applications Suitable for: IHC-P more details Species reactivity Reacts with: Human Predicted to …
WebView Rabbit Polyclonal anti-Cullin 3 Antibody (NBP2-88799). Validated Applications: WB. Validated Species: Human. Skip to main content Support: 1-888-506-6887 Items in Cart … easiest way to dice sweet potatoesWebCUL3 (Cullin-3) ubiquitin ligase complex targets multiple substrate for ubiquitination including cyclin E and of cyclin D1. Defects in CUL3 are the cause of Pseudohypoaldosteronism type 2E (PHA2E) characterized by … ct whizWebCullin-3 belongs to the cullin family of hydrophobic proteins that confer substrate specificity to the multimeric Cullin-RING E3 ubiquitin ligase (CRL) complexes by acting as scaffold … easiest way to dig out a crawl spaceWebRabbit Cullin 3 Rabbit mAb (A19623), validaed in WB,IHC and tested in Human,, Mouse,, Rat. 100% Guaranteed. ABclonal provides trial size antibody samples for target detection. Replacement to Abcam, Santa Cruz, Sigma and CST antibody. ctwhiz.comWebNEDD8 Antibody detects endogenous levels of total NEDD8. RRID: AB_2838263 引用格式: Affinity Biosciences Cat# DF6297, RRID:AB_2838263. ... is also required for neddylation of the cullin proteins (6). Protein de-neddylation is catalyzed by a number of enzymes in the cell, including a ubiquitin-specific protease USP21, the NEDP1/DEN1 ... easiest way to dig a holeWebCullin 3 is a member of the family of human Cullin genes (CUL-1, -2, -3, -4a, -4b and -5) homologous to the S. cerevisiae cdc53 gene. Cullin 3 … ct whiz vaccineWebMay 2, 2016 · Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) was used as an endogenous control for each donor. Each sample was run in triplicate to ensure accurate fold change estimation. ... Proteins were detected using primary mouse monoclonal cullin 2 (CUL-2) antibody (Santa Cruz Biotechnology, Inc., Dallas, TX, USA), Cat # sc-166506), … ctw holdings llc