WebJun 29, 2015 · ;D. 大黄素无法捕获Topo I-DNA 的可切割复合物,Topo 的抑制剂CPT作为阳性对照; 大黄素能够诱导稳定的TopoII α-DNA 可切割 复合物,Topo II 的抑制剂VP16 作为阳性对照。G. 用大黄素处理HL-60 和HL-60/MX2 细胞后,检测γ -H2AX 的表达。H. 大黄素和VP16在Topo II –缺陷型细胞HL ... Web周 珏,卢林明,张根葆(皖南医学院 1.病理解剖学教研室;2.病理生理学教研室;3.蛇毒研究所,安徽 芜湖 241002)蛇毒具有广泛的生
Effects of caspase inhibition on camptothecin‐induced …
WebThis potent antioxidant is a cytoprotectant in several experimental models. However, its neuroprotective activities are scarcely available, especially in the hippocampal region associated with... WebJun 13, 2024 · Camptothecin is an anticancer molecule which acts by targeting the human deoxyribonucleic acid topoisomerase I (Topo-I). It inhibits the enzyme by blocking the re-joining step of the cleavage reaction of Topo-I, which causes accumulation of a covalent reaction intermediate. thera ohm münchen ralf
Cell cycle analysis of HL-60 cells after doxorubicin treatment.
WebAug 1, 1993 · Since apoptosis has been associated with potential involvement of intracellular signaling linked to the Ca 2+ /calmodulin and protein kinase C transduction … WebResearch Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase specific cytotoxicity of Camptothecin (CPT) on human leukemia HL-60 cells Jennifer Man-Fan. article as: Wan et al., Polysaccharopeptides derived from. properly cited. Research Polysaccharopeptides derived from Coriolus versicolor potentiate the S-phase ... WebCamptothecin [47, 48]. binds non-covalently with topoisomerase-I and suppresses their catalytic activity, thus show- Vinblastine and its derivatives have been used ing anti-cancer properties. ... (HL-60, MCF-7) with IC50 value Due to the large diversity of endophytic fungi, (5.8, 20.15 μM) [92]. Incarxanthone B, a novel various novel cytotoxic ... therao3 portable ozone module